Are there nonstop flights from Charlotte (CLT) to Florence (FLO)?

Yes. American Eagle (airline brand) fly this route. Flight time is about 41m.

Charlotte → Florence

Charlotte Douglas International Airport (CLT) to Florence Regional Airport (FLO)・160 km

Nonstop flights available (1 airline). Flight time about 41m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.