Are there nonstop flights from Cali (CLO) to Santiago (SCL)?

Yes. JetSmart fly this route. Flight time is about 5h 23m.

What is the fastest connection from Cali (CLO) to Santiago (SCL)?

via Antofagasta ≈ 5h 55m, via Bogota ≈ 6h 20m, via Medellín ≈ 6h 34m (estimated flying time, excluding layovers).

from 17,500 ANA miles (economy, one way, based on the published award charts).

Alfonso Bonilla Aragon International Airport (CLO) to Comodoro Arturo Merino Benítez International Airport (SCL)・4,149 km

Nonstop flights available (1 airline). Flight time about 5h 23m. Nonstop return flights also operate.

With milesANA 17,500 miles+ (via BOG)Economy, one way, estimate. Tap a connection for miles by cabin.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.