Are there nonstop flights from Cleveland (CLE) to Istanbul (IST)?

No. The fastest connection is via Montréal, about 10h 59m of total flying time.

What is the fastest connection from Cleveland (CLE) to Istanbul (IST)?

via Montréal ≈ 10h 59m, via Toronto ≈ 10h 59m, via Dublin ≈ 10h 59m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Cleveland Hopkins International Airport (CLE) to İstanbul Airport (IST)・8,475 km

No nonstop flights. The fastest connection is via Montréal (YUL), about 10h 59m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

18 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.