Are there nonstop flights from Rome (CIA) to Samos Island (SMI)?

No. The fastest connection is via Rhodes, about 2h 55m of total flying time.

What is the fastest connection from Rome (CIA) to Samos Island (SMI)?

via Rhodes ≈ 2h 55m, via Prague ≈ 4h 6m (estimated flying time, excluding layovers).

Ciampino–G. B. Pastine International Airport (CIA) to Samos Airport (SMI)・1,305 km

No nonstop flights. The fastest connection is via Rhodes (RHO), about 2h 55m of flying time (layover not included).

None.

2 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.