Are there nonstop flights from Rome (CIA) to Chicago (ORD)?

No. The fastest connection is via Shannon, about 10h 9m of total flying time.

What is the fastest connection from Rome (CIA) to Chicago (ORD)?

via Shannon ≈ 10h 9m, via Edinburgh ≈ 10h 18m, via Kraków ≈ 11h 13m (estimated flying time, excluding layovers).

Ciampino–G. B. Pastine International Airport (CIA) to Chicago O'Hare International Airport (ORD)・7,765 km

No nonstop flights. The fastest connection is via Shannon (SNN), about 10h 9m of flying time (layover not included).

None.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.