Are there nonstop flights from Rome (CIA) to Orlando (MCO)?

No. The fastest connection is via Manchester, about 11h of total flying time.

What is the fastest connection from Rome (CIA) to Orlando (MCO)?

via Manchester ≈ 11h, via Edinburgh ≈ 11h 10m (estimated flying time, excluding layovers).

Ciampino–G. B. Pastine International Airport (CIA) to Orlando International Airport (MCO)・8,248 km

No nonstop flights. The fastest connection is via Manchester (MAN), about 11h of flying time (layover not included).

None.

2 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.