Are there nonstop flights from Wilkes-Barre/Scranton (AVP) to Chicago (MDW)?

No. The fastest connection is via Philadelphia, about 2h 28m of total flying time.

What is the fastest connection from Wilkes-Barre/Scranton (AVP) to Chicago (MDW)?

via Philadelphia ≈ 2h 28m, via Charlotte ≈ 3h 4m, via Myrtle Beach ≈ 3h 27m (estimated flying time, excluding layovers).

Wilkes-Barre/Scranton International Airport (AVP) to Chicago Midway International Airport (MDW)・1,001 km

No nonstop flights. The fastest connection is via Philadelphia (PHL), about 2h 28m of flying time (layover not included).

None.

3 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.