Are there nonstop flights from Appleton (ATW) to Knoxville/Maryville (TYS)?

No. The fastest connection is via Chicago, about 2h 12m of total flying time.

What is the fastest connection from Appleton (ATW) to Knoxville/Maryville (TYS)?

via Chicago ≈ 2h 12m, via Nashville ≈ 2h 22m, via Detroit ≈ 2h 24m (estimated flying time, excluding layovers).

Appleton International Airport (ATW) to McGhee Tyson Airport (TYS)・1,015 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 2h 12m of flying time (layover not included).

None.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.