Are there nonstop flights from İzmir (ADB) to Karachi (KHI)?

No. The fastest connection is via Tehran, about 5h 48m of total flying time.

What is the fastest connection from İzmir (ADB) to Karachi (KHI)?

via Tehran ≈ 5h 48m, via Dubai ≈ 5h 57m, via Istanbul ≈ 6h (estimated flying time, excluding layovers).

from 29,500 ANA miles (economy, one way, based on the published award charts).

Adnan Menderes International Airport (ADB) to Jinnah International Airport (KHI)・4,033 km

No nonstop flights. The fastest connection is via Tehran (IKA), about 5h 48m of flying time (layover not included).

With milesANA 29,500 miles+ (via IST)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.